INFLAMMATION AND FIBROSIS MAY BE DAMAGING YOUR PATIENTS’ KIDNEYS3

Inflammation and fibrosis is one of three pathophysiological driving factors behind CKD progression in patients with T2D2 and causes irreversible kidney damage.1,12

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Inflammation and fibrosis in the kidneys can lead to compromised filtration, albuminuria, and a decline in kidney function12,13,14

Click on the buttons below to read more about how inflammation and fibrosis affect the kidneys on a cellular level12,13

    Cellular expansion in kidney

    Cellular Expansion

    Cells within the glomerulus proliferate and expand, resulting in mesangial matrix expansion. There is a strong link between this process and CKD progression2,13

    Thickening around tubules in kidney

    Thickening Around Tubules

    Thickening and scarring in and around the renal tubules, which decreases renal function and increases pressure9,13

    Blood vessel scarring in kidney

    Scarring of Blood Vessels

    The hardening and scarring of the glomerulus, a tuft of capillaries that removes waste from blood, leads to an excessive loss of protein12,13

    Kidney fibrosis

    Kidney Fibrosis

    Structural damage to the kidney impairs the organ’s functionality12,13

    In the kidney, inflammation and fibrosis can lead to tissue expansion, increased pressure within the vasculature and internal structure, and eventually, to scarring that makes filtration increasingly less effective.12,13

    Learn more about the kidney damage that occurs from inflammation and fibrosis3
    Learn more

    CKD: chronic kidney disease; CV: cardiovascular; T2D: type 2 diabetes.

    References

    1. Eriksen BO, et al. Kidney Int. 2006;69(2):375–382.
    2. Mihai S, Codrici E, Popescu ID, Enciu AM, et al. Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome. J Immunol Res. 2018 Sep 6;2018:2180373. doi: 10.1155/2018/2180373. PMID: 30271792; PMCID: PMC6146775.
    3. Alicic, J. (2018). Advances in Chronic Kidney Disease, 25(2), 181–191. https://doi.org/10.1053/j.ackd.2017.12.002
    9. Imig JD, Ryan MJ. Immune and inflammatory role in renal disease. Compr Physiol. 2013 Apr;3(2):957-76. doi: 10.1002/cphy.c120028. PMID: 23720336; PMCID: PMC3803162.
    12.  Leaf IA, Duffield JS. What can target kidney fibrosis? Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i89-i97. doi: 10.1093/ndt/gfw388. PMID: 28391346.
    13.  Reidy K, Kang HM, Hostetter T, Susztak K. Molecular mechanisms of diabetic kidney disease. J Clin Invest. 2014;124(6):2333-2340. doi:10.1172/JCI72271
    14.  Klimontov VV, Korbut AI. Albuminuric and non-albuminuric patterns of chronic kidney disease in type 2 diabetes. Diabetes Metab Syndr. 2019 Jan-Feb;13(1):474-479. doi: 10.1016/ j.dsx.2018.11.014. Epub 2018