UACR + eGFR TESTING

eGFR TESTING ALONE MAY MISS EARLY SIGNS OF KIDNEY DAMAGE15

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Even patients with normal eGFR are at increased risk of CKD progression if UACR levels are increased8

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UACR is a more sensitive measure of early kidney damage, while eGFR is a more reliable indicator of later-stage loss of kidney function15,16

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The Diabetes Canada Guidelines encourage physicians to test both eGFR and UACR at least once a year in patients with type 2 diabetes5

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Increasing albuminuria and declining eGFR are independent markers of kidney damage that predict adverse renal outcomes17

 

KDIGO Monitoring Considerations8

KDIGO monitoring considerations based on patient eGFR and UACR levels
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CKD: chronic kidney disease; EASD: European Association for the Study of Diabetes; eGFR: estimated glomerular filtration rate; GFR: glomerular filtration rate; KDIGO: Kidney Disease Improving Global Outcomes; T2D: type 2 diabetes; UACR: urine albumin-to-creatinine ratio.

References

5. International Diabetes Federation. IDF Diabetes Atlas. 9th ed. Brussels; 2019. Accessed January 29, 2021. Available at: https://www.diabetesatlas.org.
8. Levin A, Stevens PE, Bilous RW, et al. (2013). Kidney disease: Improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney International Supplements, 3(1), 1-150. https://doi.org/10.1038/kisup.2012.73
15.  Campion CG, et al. Can J Kidney Health Dis. 2017;4:2054358117705371.
16. Van der Velde M, et al. Kidney Int. 2011;79(12):1341–1352
17. Cosentino F, et al.; ESC Scientific Document Group Eur Heart J. 2020;41(2):255–323.